| Customization: | Available |
|---|---|
| Powder: | Yes |
| Customized: | Customized |
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Factory Supply 99% Calcitriol Pharmaceutical Chemical API Vitamin D3 Calcitriol Powder CAS 32222-06-3 Calcitriol
| Product Name | Factory Supply 99% Calcitriol Pharmaceutical Chemical API Vitamin D3 Calcitriol Powder CAS 32222-06-3 Calcitriol |
| Appearance | White powder |
| CAS No | 32222-06-3 |
| Molecular Formula | C27H44O3 |
| Molecular Weight | 416.64 |
| EINECS | 250-963-8 |
| Keywords |
Calcitriol;Calcitriol powder;Calcitriol price
|
| Shelf Life | 2 Years Proper Storage |
| Storage | Keep in Cool Dry Place |
Calcitriol (INN), also called 1,25-dihydroxycholecalciferol or 1,25-dihydroxyvitamin D3, is the hormonally active metabolite of vitamin D with three hydroxyl groups (abbreviated 1,25-(OH)2D3 or simply 1,25(OH)2D).It was first identified by Michael F. Holick in work published in 1971.
Calcitriol increases the level of calcium (Ca2+) in the blood by increasing the uptake of calcium from the gut into the blood, increasing reabsorption of calcium by the kidneys, and possibly increasing the release of calcium into the blood from bone.
Function of Calcitriol
-Calcitriol increases blood calcium levels ([Ca2+]) by:
-Promoting absorption of dietary calcium from the gastrointestinal tract.
-Increasing renal tubular reabsorption of calcium, thus reducing the loss of calcium in the urine.
-Stimulating release of calcium from bone. For this it acts on the specific type of bone cells referred to as osteoblasts, causing them to release RANKL, which in turn activates osteoclasts.
Calcitriol acts in concert with parathyroid hormone (PTH) in all three of these roles. For instance, PTH also indirectly stimulates osteoclasts. However, the main effect of PTH is to increase the rate at which the kidneys excrete inorganic phosphate (Pi), the counterion of Ca2+. The resulting decrease in serum phosphate causes hydroxyapatite (Ca5(PO4)3OH) to dissolve out of bone thus increasing serum calcium. PTH also stimulates the production of calcitriol (see below).
Many of the effects of calcitriol are mediated by its interaction with the Calcitriol receptor, also called the vitamin D receptor or VDR. For instance, the unbound inactive form of the calcitriol receptor in intestinal epithelial cells resides in the cytoplasm. When calcitriol binds to the receptor, the ligand-receptor complex translocates to the cell nucleus, where it acts as a transcription factor promoting the expression of a gene encoding a calcium binding protein. The levels of the calcium binding protein increase enabling the cells to actively transport more calcium (Ca2+) from the intestine across the intestinal mucosa into the blood.
The maintenance of electroneutrality requires that the transport of Ca2+ ions catalyzed by the intestinal epithelial cells be accompanied by counterions, primarily inorganic phosphate. Thus calcitriol also stimulates the intestinal absorption of phosphate.
The observation that calcitriol stimulates the release of calcium from bone seems contradictory, given that sufficient levels of serum calcitriol generally prevent overall loss of calcium from bone. It is believed that the increased levels of serum calcium resulting from calcitriol-stimulated intestinal uptake causes bone to take up more calcium than it loses by hormonal stimulation of osteoclasts.Only when there are conditions, such as dietary calcium deficiency or defects in intestinal transport, which result in a reduction of serum calcium does an overall loss of calcium from bone occur.
Calcitriol also inhibits the release of calcitonin,[citation needed] a hormone which reduces blood calcium primarily by inhibiting calcium release from bone. (The effect of calcitonin on renal excretion is disputed.)
Application of Calcitriol
The main adverse drug reaction associated with calcitriol therapy is hypercalcemia - early symptoms include: nausea, vomiting,
constipation, anorexia, apathy, headache, thirst, pruritus, sweating, and/or polyuria.
Compared to other vitamin D compounds in clinical use (cholecalciferol, ergocalciferol), calcitriol has a higher risk of inducing
hypercalcemia. However, such episodes may be shorter and easier to treat due to its relatively short half-life.
Xi'an HDM Biotechnology Co., Ltd. was established in 2012. It is a high-tech professional and technical enterprise integrating R & D, production and sales. Located in the world-famous historical capital-the ancient city of Xi'an.
HDM's production base is located in Xi'an, Shaanxi. It covers an area of 35,000 square meters and a building area of 20,000 square meters. It relies on the natural rich plant resources in the mountainous areas and the production bases of Chinese medicinal materials and intermediates in southern Shaanxi. Currently it has three multi-functional plant extraction and purification production lines and one Pilot production line, a GMP production line, and a fully equipped laboratory. HDM Bio is equipped with various detection equipment such as atomic absorption spectrometry,gas chromatography,spectrophotometer,polarimeter,
automatic titrator, biochemical oxygen demand incubator, chemical oxygen demand incubator, high performance liquid chromatography Etc. to ensure product quality.
HDM's main products are plant extracts ,health products,cosmetic raw Materials,veterinary raw materials,
and pharmaceutical raw materials. Most of our products are derived from natural plants. Marketing services are available in many countries around the world, as well as Hong Kong, Macao and Taiwan regions. We have established a good and stable cooperative relationship with more than a hundred pharmaceutical,food,health products and daily chemical manufacturing companies and pharmaceutical raw material traders.
HDM Biotechnology Corporation adheres to the corporate tenet of "scientific rigor, pioneering and innovative, sincere cooperation".
HDM's corporate philosophy: "Integrity first, customer first. Sincere unity, open up the future."
With the improvement of people's quality of life in the new century, along with the vigorous development of the life and health industry, HDM Bio is facing greater opportunities and challenges. We are confident to provide more comprehensive and better scientific and technical services for scientific researchers. HDM will not humiliate its mission and create the future with you!
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